THE INFLUENCE OF LECTINS ON THE AGGREGATION OF NEUTROPHILS AND ERYTHROCYTES IN HEALTHY
HUMANS
V. F. Kirichuk,1 I. V. Voskoboy 2
1 Chairs of Normal Human Physiology and of
2 Hospital Therapy, State Medical University, Saratov
A study was made of the influence of some plant lectins on the aggregation of neutrophils and erythrocytes in healthy
humans, and the state of carbohydrate determinants of glycoprotein receptors of these cells was characterized. These carbohydrate
determinants, containing D-mannose, N-acetyl-D-glucosamin, and bD-galactose, provide neutrophils aggregation in healthy persons.
The surface receptors of erythrocytes have remains of bD-galactose, several N-acetyl-D-glucosamin, N-acetyl-neyranimic acid,
N-acetyl-D-galactosamin, L-fucose. Thus, in neutrophils and erythrocytes of healthy persons there is a definite composition of
carbohydrate determinants of glycoproteins. Changes in these carbohydrate determinants are able to increase cells aggregation and,
consequently, to disturb reological property of the blood, and to impair processes of microcirculation and throm-bose stimulation.
Key words: glycoproteins, aggregation, lectins, neutrophils, erythrocytes
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