FROM DIVERSITY OF MOLECULAR FORMS TO FUNCTIONAL SPECIALIZATION
OF OLIGOMERIC PROTEINS. NICOTINIC ACETYLCHOLINE RECEPTOR,
ACETYLCHOLINESTERASE AND Na+,K+-ATPase
T. M. Drabkina, I. I. Krivoi
Laboratory of Neuromuscular Physiology, St. Petersburg State University, St. Petersburg, Russia;
e-mail: igorKrivoi@IK4251.spb.edu
The review is devoted tp the issue of diversity of molecular forms of oligomeric proteins using as examples
members of the three protein classes: nicotinic acetylcholine receptor, acetylcholinesterase, and Na,K-ATPase.
The data are presented on the molecular structure of proteins, subunit compositions, and isoforms of subunits, as
well as on some features of gene expression. Particular emphasis has been made on the functional specialization of
different molecular forms of one and the same oligomeric protein. The three above proteins, which serve seemingly
quite different cellular processes, demonstrate many common principles of molecular mechanisms of physiological
function.
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