AGE DYMAMICS OF STABLE CHROMOSOME ABERRATION FREQUENCY IN HUMANS WITH NATURAL AND PATHOLOGICAL SENESCENCE
I. E. Vorobtsova,1 A. Yu. Kanaeva,1 I. A. Petrova,1
A. V. Semenov,1 N. M. Pleskach,2 N. M. Spivak,2 G. A. Timonina,2
V. V. Prokofieva,2 N. M. Yartseva,2 V. M. Mikhelson 2
1 Central Research Rocntgcno-Radiological Institute, People Health Ministry of Russia, and
2 Institute of Cytology, RAS, St. Petersburg, Russia;
e-mail: mikhels@mail.cytspb.rssi.ru
The age dynamics of stable chromosome aberration (SCA) frequency was analysed by fluorescent in situ hybridization
(FISH) in human blood lymphocytes derived from donors, irradiated by low doses of ionizing radiation (Chernobyl clean-up workers, nuclear
weapon testers, etc.) and patients with hereditary premature aging - Werner's syndrome and Hutchinson-Gilford's syndrome. It was found
that the level of SCA was age-dependent and increased in irradiated persons. So, the SCA level may be really an index of a so-called
"radiation senescence", and may show a real biological age of irradiated persons. The patients with Werner's syndrome demonstrate
increased SCA level in blood lymphocytes, corresponding to the premature aging of the organisms. But in the case of another form of
premature aging - Hutchinson-Gilford's syndrome - no rise of SCA level was found. Some possible reasons of such results are discussed.
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