COMPLEX EVALUATION OF WOUND HEALING PROCESS BY A DEEP WOUND RAT MODEL WITH IMPLANTED POLYCHLORVINYL CAMERA
O. V. Galibin,1 I. V. Voronkina,2, * S. N. Prokopchuk,1
M. V. Protasov,1 M. A. Solovieva,1 G. P. Pinaev 2
1 Department of Experimental Medicine, Research Center, St. Petersburg State Medical
University, and 2 Department of Cell Cultures, Institute of Cytology RAS, St. Petersburg, Russia;
* e-mail: voron@mail.cytspb.rsi.ru
A simultaneous study of wound proteolytic activity and morphological picture of the first stages of wound healing on rat
deep wound model has been shown. The process of wound healing can be evaluated by dynamics of matrix metalloproteinase activities in
wound fluid. Changes in activities of different matrix metalloproteinases correlate with different stages of healing. Implantation of
polychlorvinyl camera in the wound makes it possible to obtain the volume of wound fluid sufficient for a complex evaluation of healing
at the initial stages of wound process.
Key words: wound, wound process, wound fluid, wound model, polychlorvinyl camera, matrix
metalloproteinases
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