ASSOCIATION OF ANGIOTENSIN-CONVERTING ENZYME, ANGIOTENSINOGEN, ENDOTHELIAL NO SYNTHASE,
AND BRADYKININ RECEPTOR B2 GENE POLYMORPHISMS WITH THE CARDIOVASCULAR STRUCTURE AND FUNCTION IN
HYPERTENSIVE PATIENTS AND ATHLETES
O. V. Schneider,1 A. G. Obrezan,2 E. D. Makeeva,1
A. A. Stupnitsky,2 I. M. Spivak,1 V. M. Mikhelson1
1 Institute of Cytology RAS, St. Petersburg and 2
St. Petersburg Medical Military Academy;
e-mail: mikhels@mail.cytspb.rssi.ru
We investigated the role of gene polymorphisms in angiotensin-converting enzyme (ACE), angiotensinogen,
endothelial NO (eNO) synthase, and bradykinin receptor B2 in determining the cardiovascular system structure and
function in hypertension and "athletic heart" syndrome. Using a PCR-based method, 114 hypertensive patients and 94
athletes were genotyped for I/D polymorphism of ACE, M235T angiotensinogen (ANG), Glu298 Asp endothelial synthase
(eNOS), and type 2 receptor for bradykinin (BDKR2). Echocardiography and a 24 hour blood pressure monitoring being
performed. The (+)-allel of BDKR2 gene was associated with the left ventricular hypertrophy and greater wall
thickness in athletes and hypertensive subjects. The hypertensive patients, that were homozygous for Glu298 allele of
eNOS, demonstrated a lower level of diastolic blood pressure than did those with Glu298 Asp and Asp298 Asp genotypes.
At the same time, the ACE and AND gene polymorphisms displayed no association with the cardiac structure and
function.
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