ENHANCEMENT OF KERATINOCYTES GROWTH PROMOTING ACTIVITY OF HUMAN BLOOD
AFTER ITS IRRADIATION IN VIVO (TRANSCUTANEOUSLY) AND IN VITRO WITH VISIBLE AND INFRARED POLARIZED
LIGHT
K. A. Samoilova, O. N. Bogacheva, K. D. Obolenskaya, M. I. Blinova, N. V. Kalmykova, E. V. Kuzminikh
Institute of Cytology RAS, St. Petersburg;
e-mail: kirasam@mail.cytspb.rssi.ru ;
samoilova3@yandex.ru
To stimulate wound healing, current medicine uses various methods of phototherapy. The induced activation of
proliferative processes in the wound occurs due to development of not only local, but also systemic processes,
whose nature remains largely uninvestigated. The present work provides evidences that as early as 30 min after
irradiation of a small area of the volunteer's body surface with polychromatic visible light + infrared polarized
light (400-3400 nm, 95 % of polarization) at a therapeutic dose (12 J/cm2), soluble factors appear in the
circulating blood, which are able to stimulate proliferation of human keratinocytes in primary culture. A similar
effect was also revealed after a direct blood irradiation. A proof is provided in favor of a hypothesis that a
rapid rise of growth promoting activity of the entire circulating blood may be a consequence of transcutaneous
photomodification of the small amount of light-modified blood in superficial skin vessels, and of the effect of
such blood on its entire circulating volume. A possibility of a release into plasma of growth factors from blood
cells and complexes with a2-macroglobulin is discussed.
Key words: visible light, infrared light, wound healing, keratinocyte proliferation, growth
factors of blood, systemic effects of phototherapy
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