A ROLE FOR CAJAL BODIES IN ASSEMBLY OF THE NUCLEAR TRANSCRIPTION MACHINERY
Joseph G. Gall
Department of Embryology, Carnegie Institution of Washington, Baltimore MD 21210-3301, USA;
e-mail: gall@ciwemb.edu
Cajal bodies (CBs) are small nuclear organelles that contain the three eukaryotic RNA polymerases and variety of factors
involved in transcription and processing of all types of RNA. A number of these factors, as well as subunits of polymerase (pol) II itself, are
rapidly and specifically targeted to CBs when injected into the cell. It is suggested that pol I, pol II and pol III transcription and processing
complexes are preassembled in the CBs before transport to the sites of transcription on the chromosomes and in the nucleoli.
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