GLYCOGEN DYNAMICS IN NORMAL AND CIRRHOTICALLY ALTERED LIVER FOLLOWING GLUCOSE
ADMINISTRATION TO STARVING RATS
N. N. Bezborodkina, M. V. Kudryavtseva, S. N. Okovity, V. K. Nilova, B. N. Kudryavtsev
Institute of Cytology RAS, St. Petersburg, Russia;
1 e-mail: cellpath@mail.cytspb.rssi.ru
Using biochemical, cytofluorimetric and television cytophotometric methods, glycogen contents were studied in normal
and cirrhotic rat liver at various intervals after glucose administration to fasting animals. The obtained data indicate that after a 48 h fasting
glycogen contents in normal and cirrhotic liver are equally poor. A marked rise of glycogen content in cirrhotic liver was observed only
20-30 min after glucose administration to rats. It has been established that at all intervals after glucose administration to rats hepatocytes
of the portal lobule zone, both in normal and in cirrhotic liver, accumulate more glycogen than those of the central zone. Again, the intensity
of glycogen accumulation in cirrhotically altered liver is significantly lower than in normal liver, due, presumably, to a lower rate of glycogen
synthesis in pathologically changed liver.
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