MATRIX METALLOPROTEINASES MMP-2 AND MMP-9 OF WOUND AND BURN FLUIDS AND THEIR EFECTS
ON EXTRACELLULAR MATRIX PROTEINS
I. V. Voronkina,1, * K. V. Kokorin,1 O. V. Chulikov,2
B. A. Paramonov,3 M. I. Blinova,1 G. P. Pinaev 1
1 Institute of Cytology RAS, St. Petersburg, 2 St. Petersburg Center of Surgical
Infections Treatment, and 3 Faculty of Therminal Injuries, Military Medical Academy, St. Petersburg;
* e-mail: voron@mail.cytspb.rssi.ru
The dynamics of matrix metal oproteinases (MMP), as well as of fibronectin concentration in wound and burn fluids
was traced. The wound fluid proteolytic activity was studied by gelatin zymography method. The data on degradation of
fibronectin and various laminin isoforms by wound fluid proteases show that laminin-1, laminin-2/4 and fibronectin
were degraded by wound fluid into small fragments. Remodelling of extracellular matrix proteins occurs. Dynamics of
MMP-2 and MMP-9 content in wound or burn fluids as well as that of adhesive protein fibronectin content could be
used as a base for development of method of controlling the extracellular matrix remodelling process.
Key words: matrix metalloproteinases, extracellular matrix, wound fluid, wound healing
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